| A number of primary and secondary prevention trials , including angiographic studies, have indicated that a decrease in dietary saturated fat and cholesterol produces a decrease in the blood levels of cholesterol and low density lipoprotein (LDL) cholesterol, leading to a decrease in coronary artery disease (CAD) (1). Increasing evidence indicates that the oxidation of LDL in human beings is atherogenic. Of the three major antioxidants , Vitamin E, beta carotene and vitamin C, the evidence for a strong and independent inverse association with CAD is strongest with vitamin E. |