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Document Summary
Title Antioxidants in Pre-eclampsia
Description Antioxidants, pregnancy, oxidative stress, clinical predictors
Creation Date 01 June 1999
Doc type Article
Document Abstract:
Pre-eclampsia is a systemic pregnancy syndrome, characterised by reduced uteroplacental blood flow, diffuse endothelial dysfunction, increased peripheral vascular resistance, hypertension, coagulation abnormalities, elevations of maternal leukocyte-derived cytokines, hyperlipidemia, proteinuria, and oedema. The hypotheses suggest reactive oxygen species or their metabolites (oxidative stress) ultimately compromise the "defensive" vasodilatory, anti-aggregatory, and barrier functioning of the vascular endothelium due to uncontrolled lipid oxidation.
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