| It is over 25 years since copper deficiency was first delineated in Menkes Disease. This advanced our understanding of the clinical, biochemical and molecular essentiality of copper. This rare genetic disorder is X-linked, manifests from early pregnancy due to failure of copper transport via the placenta and results in steely hair, cutis laxa, atonia, cardiomyopathy, and mental retardation, with death in early childhood |